| Difficult Run to Santa Venerina | 4,772.26 mi (7,680.21 km) |
| Difficult Run to Santeramo in Colle | 4,726.19 mi (7,606.06 km) |
| Difficult Run to Santo Stefano di Magra | 4,307.47 mi (6,932.20 km) |
| Difficult Run to Santo Stino di Livenza | 4,373.20 mi (7,037.98 km) |
| Difficult Run to Sarezzo | 4,270.90 mi (6,873.34 km) |
| Difficult Run to Sarno | 4,631.13 mi (7,453.08 km) |
| Difficult Run to Saronno | 4,221.98 mi (6,794.63 km) |
| Difficult Run to Sarzana | 4,311.04 mi (6,937.96 km) |
| Difficult Run to Sassari | 4,362.46 mi (7,020.71 km) |
| Difficult Run to Sasso Marconi | 4,357.32 mi (7,012.43 km) |
| Difficult Run to Sassuolo | 4,332.21 mi (6,972.03 km) |
| Difficult Run to Sava | 4,776.42 mi (7,686.91 km) |
| Difficult Run to Saviano | 4,623.02 mi (7,440.03 km) |
| Difficult Run to Savigliano | 4,192.19 mi (6,746.68 km) |
| Difficult Run to Savignano sul Panaro | 4,345.18 mi (6,992.89 km) |
