| Difficult Run to Savignano sul Rubicone | 4,417.17 mi (7,108.74 km) |
| Difficult Run to Savona | 4,240.17 mi (6,823.89 km) |
| Difficult Run to Scafati | 4,629.42 mi (7,450.34 km) |
| Difficult Run to Scalea | 4,720.96 mi (7,597.65 km) |
| Difficult Run to Scandiano | 4,326.64 mi (6,963.05 km) |
| Difficult Run to Scandicci | 4,376.56 mi (7,043.40 km) |
| Difficult Run to Schio | 4,317.96 mi (6,949.08 km) |
| Difficult Run to Sciacca | 4,685.23 mi (7,540.15 km) |
| Difficult Run to Scicli | 4,786.73 mi (7,703.51 km) |
| Difficult Run to Scordia | 4,774.01 mi (7,683.02 km) |
| Difficult Run to Scorze | 4,354.46 mi (7,007.82 km) |
| Difficult Run to Sedico | 4,335.81 mi (6,977.81 km) |
| Difficult Run to Sedriano | 4,223.50 mi (6,797.07 km) |
| Difficult Run to Segni | 4,528.94 mi (7,288.63 km) |
| Difficult Run to Segrate | 4,237.39 mi (6,819.43 km) |
