| Difficult Run to Selargius | 4,440.90 mi (7,146.94 km) |
| Difficult Run to Selvazzano Dentro | 4,347.02 mi (6,995.85 km) |
| Difficult Run to Senago | 4,227.46 mi (6,803.44 km) |
| Difficult Run to Senigallia | 4,465.70 mi (7,186.85 km) |
| Difficult Run to Seravezza | 4,326.72 mi (6,963.18 km) |
| Difficult Run to Seregno | 4,228.18 mi (6,804.60 km) |
| Difficult Run to Seriate | 4,249.21 mi (6,838.44 km) |
| Difficult Run to Sermoneta | 4,532.25 mi (7,293.95 km) |
| Difficult Run to Serramanna | 4,423.98 mi (7,119.71 km) |
| Difficult Run to Serravalle Pistoiese | 4,356.16 mi (7,010.57 km) |
| Difficult Run to Sessa Aurunca | 4,585.66 mi (7,379.90 km) |
| Difficult Run to Sesto Calende | 4,201.25 mi (6,761.26 km) |
| Difficult Run to Sesto Fiorentino | 4,374.34 mi (7,039.83 km) |
| Difficult Run to Sesto San Giovanni | 4,233.35 mi (6,812.91 km) |
| Difficult Run to Sestri Levante | 4,281.10 mi (6,889.77 km) |
