| Difficult Run to Solofra | 4,640.81 mi (7,468.67 km) |
| Difficult Run to Somma Lombardo | 4,205.69 mi (6,768.41 km) |
| Difficult Run to Somma Vesuviana | 4,621.13 mi (7,436.99 km) |
| Difficult Run to Sommacampagna | 4,306.79 mi (6,931.11 km) |
| Difficult Run to Sona | 4,304.98 mi (6,928.19 km) |
| Difficult Run to Sondrio | 4,240.08 mi (6,823.75 km) |
| Difficult Run to Sora | 4,554.16 mi (7,329.21 km) |
| Difficult Run to Sorbolo | 4,307.91 mi (6,932.91 km) |
| Difficult Run to Soresina | 4,268.06 mi (6,868.78 km) |
| Difficult Run to Sorisole | 4,244.89 mi (6,831.48 km) |
| Difficult Run to Sorrento | 4,627.35 mi (7,447.01 km) |
| Difficult Run to Sorso | 4,360.85 mi (7,018.10 km) |
| Difficult Run to Sortino | 4,787.51 mi (7,704.75 km) |
| Difficult Run to Soverato Marina | 4,797.74 mi (7,721.21 km) |
| Difficult Run to Sovicille | 4,394.55 mi (7,072.35 km) |
