| Difficult Run to Spello | 4,467.51 mi (7,189.76 km) |
| Difficult Run to Spilamberto | 4,342.79 mi (6,989.04 km) |
| Difficult Run to Spilimbergo | 4,368.27 mi (7,030.04 km) |
| Difficult Run to Spinea | 4,359.30 mi (7,015.61 km) |
| Difficult Run to Spoleto | 4,476.26 mi (7,203.85 km) |
| Difficult Run to Spoltore | 4,550.36 mi (7,323.10 km) |
| Difficult Run to Spresiano | 4,353.29 mi (7,005.94 km) |
| Difficult Run to Squinzano | 4,796.22 mi (7,718.77 km) |
| Difficult Run to Statte | 4,754.02 mi (7,650.85 km) |
| Difficult Run to Stezzano | 4,247.52 mi (6,835.73 km) |
| Difficult Run to Strada | 4,387.93 mi (7,061.69 km) |
| Difficult Run to Stradella | 4,250.70 mi (6,840.84 km) |
| Difficult Run to Striano | 4,628.92 mi (7,449.53 km) |
| Difficult Run to Subiaco | 4,523.66 mi (7,280.12 km) |
| Difficult Run to Sulmona | 4,555.75 mi (7,331.78 km) |
