| Difficult Run to Ede | 3,896.79 mi (6,271.28 km) |
| Difficult Run to Eemnes | 3,875.26 mi (6,236.63 km) |
| Difficult Run to Eerbeek | 3,910.96 mi (6,294.08 km) |
| Difficult Run to Eersel | 3,901.07 mi (6,278.17 km) |
| Difficult Run to Eijsden | 3,931.90 mi (6,327.78 km) |
| Difficult Run to Eindhoven | 3,905.55 mi (6,285.37 km) |
| Difficult Run to Elburg | 3,893.68 mi (6,266.26 km) |
| Difficult Run to Emmeloord | 3,883.16 mi (6,249.35 km) |
| Difficult Run to Emmen | 3,925.84 mi (6,318.03 km) |
| Difficult Run to Enkhuizen | 3,865.85 mi (6,221.48 km) |
| Difficult Run to Enschede | 3,940.81 mi (6,342.12 km) |
| Difficult Run to Epe | 3,901.47 mi (6,278.80 km) |
| Difficult Run to Ermelo | 3,888.39 mi (6,257.76 km) |
| Difficult Run to Etten-Leur | 3,868.19 mi (6,225.25 km) |
| Difficult Run to Franeker | 3,862.38 mi (6,215.90 km) |
