| Difficult Run to Schiedam | 3,850.07 mi (6,196.08 km) |
| Difficult Run to Schijndel | 3,898.78 mi (6,274.48 km) |
| Difficult Run to Schinnen | 3,934.33 mi (6,331.69 km) |
| Difficult Run to Schoonhoven | 3,867.08 mi (6,223.46 km) |
| Difficult Run to Simpelveld | 3,941.48 mi (6,343.19 km) |
| Difficult Run to Sint Anthonis | 3,916.32 mi (6,302.71 km) |
| Difficult Run to Sint Willebrord | 3,866.95 mi (6,223.25 km) |
| Difficult Run to Sint-Michielsgestel | 3,895.12 mi (6,268.59 km) |
| Difficult Run to Sint-Oedenrode | 3,901.25 mi (6,278.46 km) |
| Difficult Run to Sittard | 3,932.33 mi (6,328.47 km) |
| Difficult Run to Sliedrecht | 3,867.15 mi (6,223.58 km) |
| Difficult Run to Slochteren | 3,910.70 mi (6,293.67 km) |
| Difficult Run to Sluis | 3,824.63 mi (6,155.15 km) |
| Difficult Run to Sneek | 3,871.47 mi (6,230.53 km) |
| Difficult Run to Soest | 3,878.92 mi (6,242.52 km) |
