| Difficult Run to Entroncamento | 3,592.94 mi (5,782.27 km) |
| Difficult Run to Ericeira | 3,559.61 mi (5,728.65 km) |
| Difficult Run to Ermezinde | 3,543.14 mi (5,702.13 km) |
| Difficult Run to Esmoriz | 3,546.09 mi (5,706.88 km) |
| Difficult Run to Espinho | 3,544.06 mi (5,703.61 km) |
| Difficult Run to Esposende | 3,523.90 mi (5,671.17 km) |
| Difficult Run to Estarreja | 3,554.28 mi (5,720.07 km) |
| Difficult Run to Estoril | 3,567.55 mi (5,741.41 km) |
| Difficult Run to Estremoz | 3,653.29 mi (5,879.40 km) |
| Difficult Run to Evora | 3,645.53 mi (5,866.91 km) |
| Difficult Run to Fafe | 3,555.71 mi (5,722.36 km) |
| Difficult Run to Falagueira | 3,574.60 mi (5,752.76 km) |
| Difficult Run to Famalicao | 3,539.69 mi (5,696.57 km) |
| Difficult Run to Fanzeres | 3,545.22 mi (5,705.49 km) |
| Difficult Run to Faro | 3,687.84 mi (5,935.00 km) |
