| Difficult Run to Sesimbra | 3,589.47 mi (5,776.70 km) |
| Difficult Run to Setubal | 3,597.54 mi (5,789.68 km) |
| Difficult Run to Sever do Vouga | 3,564.43 mi (5,736.39 km) |
| Difficult Run to Silves | 3,657.68 mi (5,886.46 km) |
| Difficult Run to Sines | 3,614.70 mi (5,817.30 km) |
| Difficult Run to Sintra | 3,565.47 mi (5,738.07 km) |
| Difficult Run to Sobrado de Paiva | 3,561.53 mi (5,731.73 km) |
| Difficult Run to Sobral de Monte Agraco | 3,571.27 mi (5,747.40 km) |
| Difficult Run to Soure | 3,569.28 mi (5,744.20 km) |
| Difficult Run to Tabua | 3,590.58 mi (5,778.47 km) |
| Difficult Run to Tavira | 3,699.18 mi (5,953.26 km) |
| Difficult Run to Tomar | 3,591.85 mi (5,780.52 km) |
| Difficult Run to Tondela | 3,583.83 mi (5,767.62 km) |
| Difficult Run to Torre de Moncorvo | 3,611.90 mi (5,812.80 km) |
| Difficult Run to Torres Novas | 3,589.69 mi (5,777.06 km) |
