| Difficult Run to Sangeorgiu de Mures | 4,818.37 mi (7,754.41 km) |
| Difficult Run to Sangeorz-Bai | 4,793.52 mi (7,714.43 km) |
| Difficult Run to Sannicolau Mare | 4,686.22 mi (7,541.74 km) |
| Difficult Run to Santana | 4,710.43 mi (7,580.70 km) |
| Difficult Run to Satu Mare | 4,708.54 mi (7,577.66 km) |
| Difficult Run to Scobinti | 4,878.00 mi (7,850.39 km) |
| Difficult Run to Scornicesti | 4,902.08 mi (7,889.14 km) |
| Difficult Run to Sebes | 4,807.20 mi (7,736.45 km) |
| Difficult Run to Seini | 4,725.31 mi (7,604.66 km) |
| Difficult Run to Sfantu-Gheorghe | 4,897.34 mi (7,881.51 km) |
| Difficult Run to Sibiu | 4,836.69 mi (7,783.90 km) |
| Difficult Run to Sighetu Marmatiei | 4,741.31 mi (7,630.40 km) |
| Difficult Run to Sighisoara | 4,844.38 mi (7,796.27 km) |
| Difficult Run to Simeria | 4,789.60 mi (7,708.11 km) |
| Difficult Run to Sinaia | 4,909.38 mi (7,900.88 km) |
