| Difficult Run to El Astillero | 3,711.26 mi (5,972.69 km) |
| Difficult Run to El Ejido | 3,949.46 mi (6,356.04 km) |
| Difficult Run to El Escorial | 3,773.16 mi (6,072.31 km) |
| Difficult Run to El Espinar | 3,763.48 mi (6,056.74 km) |
| Difficult Run to El Molar | 3,794.95 mi (6,107.39 km) |
| Difficult Run to El Prat de Llobregat | 4,045.41 mi (6,510.45 km) |
| Difficult Run to El Puerto de Santa Maria | 3,786.08 mi (6,093.10 km) |
| Difficult Run to El Viso del Alcor | 3,787.66 mi (6,095.65 km) |
| Difficult Run to Elche | 4,006.93 mi (6,448.54 km) |
| Difficult Run to Elda | 3,995.60 mi (6,430.29 km) |
| Difficult Run to Elgoibar | 3,781.33 mi (6,085.46 km) |
| Difficult Run to Erandio | 3,753.11 mi (6,040.05 km) |
| Difficult Run to Ermua | 3,778.16 mi (6,080.36 km) |
| Difficult Run to Esparraguera | 4,028.39 mi (6,483.07 km) |
| Difficult Run to Espartinas | 3,767.80 mi (6,063.69 km) |
