| Difficult Run to Esplugas de Llobregat | 4,043.37 mi (6,507.18 km) |
| Difficult Run to Estepa | 3,831.90 mi (6,166.85 km) |
| Difficult Run to Estepona | 3,844.73 mi (6,187.50 km) |
| Difficult Run to Felanitx | 4,152.95 mi (6,683.52 km) |
| Difficult Run to Fene | 3,506.19 mi (5,642.68 km) |
| Difficult Run to Fernan-Nunez | 3,828.72 mi (6,161.73 km) |
| Difficult Run to Ferrol | 3,502.66 mi (5,636.99 km) |
| Difficult Run to Figueras | 4,056.86 mi (6,528.88 km) |
| Difficult Run to Fortuna | 3,989.06 mi (6,419.77 km) |
| Difficult Run to Foz | 3,546.45 mi (5,707.45 km) |
| Difficult Run to Fraga | 3,958.13 mi (6,369.99 km) |
| Difficult Run to Fuengirola | 3,867.24 mi (6,223.72 km) |
| Difficult Run to Fuenlabrada | 3,797.22 mi (6,111.03 km) |
| Difficult Run to Fuensalida | 3,784.59 mi (6,090.70 km) |
| Difficult Run to Fuente Palmera | 3,808.81 mi (6,129.68 km) |
