| Difficult Run to Sabadell | 4,039.15 mi (6,500.38 km) |
| Difficult Run to Sabinanigo | 3,895.83 mi (6,269.72 km) |
| Difficult Run to Sagunto | 3,984.00 mi (6,411.63 km) |
| Difficult Run to Salamanca | 3,688.78 mi (5,936.51 km) |
| Difficult Run to Salobrena | 3,912.49 mi (6,296.54 km) |
| Difficult Run to Salou | 4,007.87 mi (6,450.04 km) |
| Difficult Run to Salt | 4,057.58 mi (6,530.05 km) |
| Difficult Run to Salvatierra de Mino | 3,523.84 mi (5,671.07 km) |
| Difficult Run to Sama | 3,626.91 mi (5,836.95 km) |
| Difficult Run to San Adrian de Besos | 4,047.89 mi (6,514.45 km) |
| Difficult Run to San Agustin de Guadalix | 3,794.91 mi (6,107.32 km) |
| Difficult Run to San Andres de la Barca | 4,036.14 mi (6,495.54 km) |
| Difficult Run to San Andres de Llevaneras | 4,055.79 mi (6,527.17 km) |
| Difficult Run to San Andres del Rabanedo | 3,648.23 mi (5,871.26 km) |
| Difficult Run to San Bartolome | 3,574.55 mi (5,752.68 km) |
