| Difficult Run to Santa Ursula | 3,508.85 mi (5,646.95 km) |
| Difficult Run to Santander | 3,710.33 mi (5,971.20 km) |
| Difficult Run to Santany | 4,155.71 mi (6,687.97 km) |
| Difficult Run to Santiago de Compostela | 3,502.37 mi (5,636.52 km) |
| Difficult Run to Santiago del Teide | 3,495.94 mi (5,626.17 km) |
| Difficult Run to Santiponce | 3,769.92 mi (6,067.10 km) |
| Difficult Run to Santomera | 3,996.29 mi (6,431.41 km) |
| Difficult Run to Santona | 3,727.02 mi (5,998.06 km) |
| Difficult Run to Santurce-Antiguo | 3,749.73 mi (6,034.60 km) |
| Difficult Run to Sarria | 3,558.15 mi (5,726.29 km) |
| Difficult Run to Sauzal | 3,510.02 mi (5,648.84 km) |
| Difficult Run to Sedavi | 3,986.27 mi (6,415.28 km) |
| Difficult Run to Segorbe | 3,968.36 mi (6,386.45 km) |
| Difficult Run to Segovia | 3,763.29 mi (6,056.43 km) |
| Difficult Run to Senmanat | 4,038.63 mi (6,499.54 km) |
