| Difficult Run to Domanic | 5,309.59 mi (8,544.96 km) |
| Difficult Run to Duragan | 5,449.28 mi (8,769.76 km) |
| Difficult Run to Duzce | 5,324.78 mi (8,569.40 km) |
| Difficult Run to Eceabat | 5,159.29 mi (8,303.07 km) |
| Difficult Run to Edirne | 5,103.57 mi (8,213.40 km) |
| Difficult Run to Edremit | 5,212.29 mi (8,388.37 km) |
| Difficult Run to Elazig | 5,739.55 mi (9,236.91 km) |
| Difficult Run to Elbistan | 5,684.69 mi (9,148.63 km) |
| Difficult Run to Eleskirt | 5,810.67 mi (9,351.37 km) |
| Difficult Run to Emet | 5,316.20 mi (8,555.60 km) |
| Difficult Run to Emirdag | 5,407.06 mi (8,701.82 km) |
| Difficult Run to Emirgazi | 5,566.71 mi (8,958.76 km) |
| Difficult Run to Enez | 5,123.83 mi (8,246.01 km) |
| Difficult Run to Erbaa | 5,542.33 mi (8,919.52 km) |
| Difficult Run to Ercis | 5,874.47 mi (9,454.04 km) |
