| Difficult Run to East Dereham | 3,694.64 mi (5,945.95 km) |
| Difficult Run to East Finchley | 3,673.75 mi (5,912.33 km) |
| Difficult Run to East Grinstead | 3,691.14 mi (5,940.32 km) |
| Difficult Run to East Ham | 3,684.42 mi (5,929.50 km) |
| Difficult Run to East Kilbride | 3,438.35 mi (5,533.49 km) |
| Difficult Run to East Retford | 3,606.59 mi (5,804.24 km) |
| Difficult Run to Eastbourne | 3,710.84 mi (5,972.02 km) |
| Difficult Run to Eastham | 3,526.73 mi (5,675.72 km) |
| Difficult Run to Eastleigh | 3,639.18 mi (5,856.70 km) |
| Difficult Run to Eastwood | 3,598.36 mi (5,791.00 km) |
| Difficult Run to Ebbw Vale | 3,545.84 mi (5,706.48 km) |
| Difficult Run to Eccles | 3,548.30 mi (5,710.44 km) |
| Difficult Run to Ecclesall | 3,583.88 mi (5,767.69 km) |
| Difficult Run to Ecclesfield | 3,583.41 mi (5,766.95 km) |
| Difficult Run to Eccleston | 3,531.57 mi (5,683.51 km) |
