| Difficult Run to Eckington | 3,590.22 mi (5,777.91 km) |
| Difficult Run to Edgware | 3,669.16 mi (5,904.94 km) |
| Difficult Run to Edinburgh | 3,472.77 mi (5,588.88 km) |
| Difficult Run to Edmonton | 3,677.44 mi (5,918.28 km) |
| Difficult Run to Egg Buckland | 3,535.70 mi (5,690.17 km) |
| Difficult Run to Elgin | 3,442.83 mi (5,540.70 km) |
| Difficult Run to Elland | 3,564.21 mi (5,736.04 km) |
| Difficult Run to Ellesmere Port | 3,529.94 mi (5,680.89 km) |
| Difficult Run to Ellon | 3,491.57 mi (5,619.15 km) |
| Difficult Run to Eltham | 3,686.09 mi (5,932.18 km) |
| Difficult Run to Ely | 3,673.78 mi (5,912.37 km) |
| Difficult Run to Emsworth | 3,658.78 mi (5,888.24 km) |
| Difficult Run to Enfield | 3,676.23 mi (5,916.32 km) |
| Difficult Run to Enfield Lock | 3,678.09 mi (5,919.32 km) |
| Difficult Run to Englefield Green | 3,661.16 mi (5,892.08 km) |
