| Difficult Run to Enniskillen | 3,324.72 mi (5,350.62 km) |
| Difficult Run to Epping | 3,682.86 mi (5,926.99 km) |
| Difficult Run to Epsom | 3,675.62 mi (5,915.33 km) |
| Difficult Run to Erdington | 3,586.87 mi (5,772.51 km) |
| Difficult Run to Erith | 3,690.57 mi (5,939.39 km) |
| Difficult Run to Esher | 3,670.88 mi (5,907.71 km) |
| Difficult Run to Euxton | 3,531.73 mi (5,683.77 km) |
| Difficult Run to Evesham | 3,591.14 mi (5,779.38 km) |
| Difficult Run to Evington | 3,615.65 mi (5,818.82 km) |
| Difficult Run to Ewell | 3,676.04 mi (5,916.02 km) |
| Difficult Run to Exeter | 3,553.75 mi (5,719.21 km) |
| Difficult Run to Exmouth | 3,560.67 mi (5,730.35 km) |
| Difficult Run to Failsworth | 3,554.96 mi (5,721.15 km) |
| Difficult Run to Falkirk | 3,449.64 mi (5,551.65 km) |
| Difficult Run to Falmouth | 3,500.26 mi (5,633.13 km) |
