| Difficult Run to Saint Ives | 3,661.59 mi (5,892.76 km) |
| Difficult Run to Saint Ives | 3,481.67 mi (5,603.21 km) |
| Difficult Run to Saint Neots | 3,656.08 mi (5,883.89 km) |
| Difficult Run to Sale | 3,550.07 mi (5,713.29 km) |
| Difficult Run to Salford | 3,550.10 mi (5,713.34 km) |
| Difficult Run to Salisbury | 3,618.79 mi (5,823.87 km) |
| Difficult Run to Saltash | 3,531.41 mi (5,683.26 km) |
| Difficult Run to Saltcoats | 3,416.99 mi (5,499.11 km) |
| Difficult Run to Sandbach | 3,553.54 mi (5,718.87 km) |
| Difficult Run to Sanderstead | 3,683.19 mi (5,927.52 km) |
| Difficult Run to Sandhurst | 3,653.52 mi (5,879.77 km) |
| Difficult Run to Sandiacre | 3,600.78 mi (5,794.89 km) |
| Difficult Run to Sandown | 3,654.11 mi (5,880.71 km) |
| Difficult Run to Sandridge | 3,664.36 mi (5,897.22 km) |
| Difficult Run to Sandy | 3,657.07 mi (5,885.49 km) |
