| Difficult Run to Scarborough | 3,608.88 mi (5,807.94 km) |
| Difficult Run to Scartho | 3,635.68 mi (5,851.06 km) |
| Difficult Run to Scunthorpe | 3,612.97 mi (5,814.51 km) |
| Difficult Run to Seacombe | 3,522.30 mi (5,668.60 km) |
| Difficult Run to Seacroft | 3,576.48 mi (5,755.80 km) |
| Difficult Run to Seaford | 3,703.42 mi (5,960.07 km) |
| Difficult Run to Seaham | 3,562.07 mi (5,732.59 km) |
| Difficult Run to Sedgley | 3,575.06 mi (5,753.51 km) |
| Difficult Run to Selby | 3,592.53 mi (5,781.62 km) |
| Difficult Run to Selsey | 3,667.44 mi (5,902.17 km) |
| Difficult Run to Selston | 3,597.48 mi (5,789.59 km) |
| Difficult Run to Sevenoaks | 3,695.48 mi (5,947.31 km) |
| Difficult Run to Shanklin | 3,653.72 mi (5,880.09 km) |
| Difficult Run to Sheerness | 3,715.13 mi (5,978.93 km) |
| Difficult Run to Sheffield | 3,584.60 mi (5,768.86 km) |
