| Difficult Run to Sheldon | 3,591.21 mi (5,779.50 km) |
| Difficult Run to Shenfield | 3,692.97 mi (5,943.26 km) |
| Difficult Run to Shenley Brook End | 3,639.80 mi (5,857.69 km) |
| Difficult Run to Shenley Church End | 3,639.56 mi (5,857.31 km) |
| Difficult Run to Shepperton | 3,666.53 mi (5,900.72 km) |
| Difficult Run to Shepshed | 3,603.67 mi (5,799.55 km) |
| Difficult Run to Shepton Mallet | 3,584.97 mi (5,769.46 km) |
| Difficult Run to Sherborne | 3,591.27 mi (5,779.59 km) |
| Difficult Run to Shevington | 3,532.75 mi (5,685.41 km) |
| Difficult Run to Shildon | 3,553.99 mi (5,719.59 km) |
| Difficult Run to Shipley | 3,563.85 mi (5,735.46 km) |
| Difficult Run to Shirebrook | 3,597.99 mi (5,790.41 km) |
| Difficult Run to Shiremoor | 3,552.18 mi (5,716.69 km) |
| Difficult Run to Shirley | 3,683.30 mi (5,927.70 km) |
| Difficult Run to Shoeburyness | 3,714.61 mi (5,978.08 km) |
