| Difficult Run to Shoreham-by-Sea | 3,686.58 mi (5,932.98 km) |
| Difficult Run to Shotley Bridge | 3,541.56 mi (5,699.60 km) |
| Difficult Run to Shrewsbury | 3,546.40 mi (5,707.38 km) |
| Difficult Run to Sidcup | 3,688.69 mi (5,936.38 km) |
| Difficult Run to Sidmouth | 3,566.72 mi (5,740.08 km) |
| Difficult Run to Sileby | 3,612.04 mi (5,813.02 km) |
| Difficult Run to Sittingbourne | 3,716.63 mi (5,981.33 km) |
| Difficult Run to Skegness | 3,661.04 mi (5,891.88 km) |
| Difficult Run to Skelmersdale | 3,529.75 mi (5,680.59 km) |
| Difficult Run to Skipton | 3,552.04 mi (5,716.46 km) |
| Difficult Run to Sleaford | 3,634.21 mi (5,848.70 km) |
| Difficult Run to Slough | 3,658.71 mi (5,888.13 km) |
| Difficult Run to Small Heath | 3,587.42 mi (5,773.40 km) |
| Difficult Run to Smethwick | 3,582.21 mi (5,765.01 km) |
| Difficult Run to Snaresbrook | 3,681.54 mi (5,924.87 km) |
