| Difficult Run to Stanmore | 3,667.50 mi (5,902.26 km) |
| Difficult Run to Stannington | 3,581.71 mi (5,764.21 km) |
| Difficult Run to Stansted Mountfitchet | 3,682.12 mi (5,925.79 km) |
| Difficult Run to Stanwell | 3,664.60 mi (5,897.60 km) |
| Difficult Run to Stapleford | 3,601.34 mi (5,795.79 km) |
| Difficult Run to Staveley | 3,591.61 mi (5,780.14 km) |
| Difficult Run to Stepney | 3,680.66 mi (5,923.45 km) |
| Difficult Run to Stevenage | 3,665.86 mi (5,899.63 km) |
| Difficult Run to Stevenston | 3,418.05 mi (5,500.81 km) |
| Difficult Run to Stirling | 3,442.12 mi (5,539.55 km) |
| Difficult Run to Stockport | 3,557.20 mi (5,724.77 km) |
| Difficult Run to Stocksbridge | 3,578.07 mi (5,758.34 km) |
| Difficult Run to Stockton-on-Tees | 3,567.82 mi (5,741.85 km) |
| Difficult Run to Stoke Gifford | 3,578.26 mi (5,758.66 km) |
| Difficult Run to Stoke-on-Trent | 3,563.66 mi (5,735.16 km) |
