| Difficult Run to Stone | 3,566.93 mi (5,740.42 km) |
| Difficult Run to Stonehaven | 3,493.25 mi (5,621.84 km) |
| Difficult Run to Stourbridge | 3,575.69 mi (5,754.52 km) |
| Difficult Run to Stowmarket | 3,707.91 mi (5,967.31 km) |
| Difficult Run to Stranraer | 3,418.85 mi (5,502.11 km) |
| Difficult Run to Stratford | 3,681.83 mi (5,925.34 km) |
| Difficult Run to Stratford-upon-Avon | 3,598.84 mi (5,791.78 km) |
| Difficult Run to Stratton Saint Margaret | 3,609.08 mi (5,808.25 km) |
| Difficult Run to Streatham | 3,679.44 mi (5,921.49 km) |
| Difficult Run to Street | 3,578.46 mi (5,758.97 km) |
| Difficult Run to Streetly | 3,583.95 mi (5,767.80 km) |
| Difficult Run to Stretford | 3,550.18 mi (5,713.46 km) |
| Difficult Run to Strood | 3,704.75 mi (5,962.21 km) |
| Difficult Run to Stroud | 3,587.29 mi (5,773.19 km) |
| Difficult Run to Sudbury | 3,668.66 mi (5,904.14 km) |
