| Difficult Run to Deville-les-Rouen | 3,773.73 mi (6,073.23 km) |
| Difficult Run to Dieppe | 3,764.04 mi (6,057.63 km) |
| Difficult Run to Digne-les-Bains | 4,148.18 mi (6,675.85 km) |
| Difficult Run to Dijon | 3,998.87 mi (6,435.56 km) |
| Difficult Run to Dinan | 3,665.95 mi (5,899.77 km) |
| Difficult Run to Dinard | 3,661.36 mi (5,892.39 km) |
| Difficult Run to Divonne-les-Bains | 4,075.12 mi (6,558.27 km) |
| Difficult Run to Dole | 4,025.53 mi (6,478.46 km) |
| Difficult Run to Dombasle-sur-Meurthe | 4,017.69 mi (6,465.85 km) |
| Difficult Run to Domerat | 3,918.53 mi (6,306.27 km) |
| Difficult Run to Domont | 3,838.49 mi (6,177.45 km) |
| Difficult Run to Douai | 3,835.59 mi (6,172.79 km) |
| Difficult Run to Douarnenez | 3,575.10 mi (5,753.56 km) |
| Difficult Run to Douchy-les-Mines | 3,850.22 mi (6,196.33 km) |
| Difficult Run to Dourdan | 3,837.98 mi (6,176.63 km) |
