| Difficult Run to Draguignan | 4,175.76 mi (6,720.24 km) |
| Difficult Run to Drancy | 3,846.19 mi (6,189.84 km) |
| Difficult Run to Draveil | 3,850.76 mi (6,197.19 km) |
| Difficult Run to Dreux | 3,805.32 mi (6,124.07 km) |
| Difficult Run to Dugny | 3,844.17 mi (6,186.59 km) |
| Difficult Run to Dunkerque | 3,790.39 mi (6,100.05 km) |
| Difficult Run to Eaubonne | 3,837.46 mi (6,175.79 km) |
| Difficult Run to Echirolles | 4,093.12 mi (6,587.23 km) |
| Difficult Run to Ecully | 4,033.18 mi (6,490.78 km) |
| Difficult Run to Elancourt | 3,829.20 mi (6,162.51 km) |
| Difficult Run to Elbeuf | 3,776.51 mi (6,077.70 km) |
| Difficult Run to Elne | 4,047.01 mi (6,513.04 km) |
| Difficult Run to Enghien-les-Bains | 3,839.19 mi (6,178.58 km) |
| Difficult Run to Entraigues-sur-la-Sorgue | 4,092.75 mi (6,586.65 km) |
| Difficult Run to Epernay | 3,906.61 mi (6,287.08 km) |
