| Drobeta-Turnu Severin to Orbetello | 592.04 mi (952.79 km) |
| Drobeta-Turnu Severin to Oria | 382.89 mi (616.21 km) |
| Drobeta-Turnu Severin to Oristano | 788.13 mi (1,268.37 km) |
| Drobeta-Turnu Severin to Orta Nova | 418.19 mi (673.00 km) |
| Drobeta-Turnu Severin to Orte | 535.07 mi (861.11 km) |
| Drobeta-Turnu Severin to Ortona | 442.35 mi (711.90 km) |
| Drobeta-Turnu Severin to Orvieto | 542.63 mi (873.27 km) |
| Drobeta-Turnu Severin to Orzinuovi | 622.71 mi (1,002.16 km) |
| Drobeta-Turnu Severin to Osimo | 461.77 mi (743.15 km) |
| Drobeta-Turnu Severin to Ospitaletto | 616.10 mi (991.51 km) |
| Drobeta-Turnu Severin to Ostuni | 372.46 mi (599.42 km) |
| Drobeta-Turnu Severin to Ottaviano | 489.85 mi (788.33 km) |
| Drobeta-Turnu Severin to Ovada | 687.65 mi (1,106.66 km) |
| Drobeta-Turnu Severin to Ozieri | 747.04 mi (1,202.25 km) |
| Drobeta-Turnu Severin to Paceco | 696.10 mi (1,120.27 km) |
