| Drobeta-Turnu Severin to Sacile | 501.45 mi (807.01 km) |
| Drobeta-Turnu Severin to Sala Consilina | 462.80 mi (744.80 km) |
| Drobeta-Turnu Severin to Salemi | 694.65 mi (1,117.93 km) |
| Drobeta-Turnu Severin to Salerno | 484.75 mi (780.14 km) |
| Drobeta-Turnu Severin to Salo | 593.96 mi (955.88 km) |
| Drobeta-Turnu Severin to Salsomaggiore Terme | 621.50 mi (1,000.21 km) |
| Drobeta-Turnu Severin to Saluzzo | 744.20 mi (1,197.68 km) |
| Drobeta-Turnu Severin to Salzano | 517.24 mi (832.41 km) |
| Drobeta-Turnu Severin to Samarate | 678.54 mi (1,092.01 km) |
| Drobeta-Turnu Severin to San Benedetto del Tronto | 452.19 mi (727.74 km) |
| Drobeta-Turnu Severin to San Biagio di Callalta | 505.18 mi (813.01 km) |
| Drobeta-Turnu Severin to San Bonifacio | 557.22 mi (896.77 km) |
| Drobeta-Turnu Severin to San Casciano in Val di Pesa | 571.90 mi (920.38 km) |
| Drobeta-Turnu Severin to San Cataldo | 668.50 mi (1,075.85 km) |
| Drobeta-Turnu Severin to San Cesareo | 532.29 mi (856.64 km) |
