| Drobeta-Turnu Severin to Savignano sul Rubicone | 507.73 mi (817.11 km) |
| Drobeta-Turnu Severin to Savona | 698.09 mi (1,123.47 km) |
| Drobeta-Turnu Severin to Scafati | 491.66 mi (791.25 km) |
| Drobeta-Turnu Severin to Scalea | 482.98 mi (777.28 km) |
| Drobeta-Turnu Severin to Scandiano | 587.84 mi (946.04 km) |
| Drobeta-Turnu Severin to Scandicci | 570.50 mi (918.14 km) |
| Drobeta-Turnu Severin to Schio | 554.68 mi (892.67 km) |
| Drobeta-Turnu Severin to Sciacca | 699.30 mi (1,125.42 km) |
| Drobeta-Turnu Severin to Scicli | 682.52 mi (1,098.40 km) |
| Drobeta-Turnu Severin to Scordia | 649.21 mi (1,044.81 km) |
| Drobeta-Turnu Severin to Scorze | 517.77 mi (833.26 km) |
| Drobeta-Turnu Severin to Sedico | 521.79 mi (839.74 km) |
| Drobeta-Turnu Severin to Sedriano | 669.59 mi (1,077.61 km) |
| Drobeta-Turnu Severin to Segni | 526.15 mi (846.76 km) |
| Drobeta-Turnu Severin to Segrate | 653.68 mi (1,052.00 km) |
