| Drobeta-Turnu Severin to Selargius | 785.20 mi (1,263.66 km) |
| Drobeta-Turnu Severin to Selvazzano Dentro | 532.94 mi (857.69 km) |
| Drobeta-Turnu Severin to Senago | 661.59 mi (1,064.73 km) |
| Drobeta-Turnu Severin to Senigallia | 471.43 mi (758.69 km) |
| Drobeta-Turnu Severin to Seravezza | 614.79 mi (989.40 km) |
| Drobeta-Turnu Severin to Seregno | 658.46 mi (1,059.68 km) |
| Drobeta-Turnu Severin to Seriate | 633.53 mi (1,019.57 km) |
| Drobeta-Turnu Severin to Sermoneta | 531.80 mi (855.84 km) |
| Drobeta-Turnu Severin to Serramanna | 789.81 mi (1,271.08 km) |
| Drobeta-Turnu Severin to Serravalle Pistoiese | 586.33 mi (943.61 km) |
| Drobeta-Turnu Severin to Sessa Aurunca | 499.24 mi (803.45 km) |
| Drobeta-Turnu Severin to Sesto Calende | 685.93 mi (1,103.90 km) |
| Drobeta-Turnu Severin to Sesto Fiorentino | 569.05 mi (915.80 km) |
| Drobeta-Turnu Severin to Sesto San Giovanni | 656.71 mi (1,056.87 km) |
| Drobeta-Turnu Severin to Sestri Levante | 653.58 mi (1,051.84 km) |
