| Drobeta-Turnu Severin to Sestu | 786.61 mi (1,265.93 km) |
| Drobeta-Turnu Severin to Settimo Torinese | 728.41 mi (1,172.26 km) |
| Drobeta-Turnu Severin to Seveso | 661.47 mi (1,064.53 km) |
| Drobeta-Turnu Severin to Sezze | 529.53 mi (852.19 km) |
| Drobeta-Turnu Severin to Siano | 482.51 mi (776.52 km) |
| Drobeta-Turnu Severin to Siena | 569.59 mi (916.66 km) |
| Drobeta-Turnu Severin to Signa | 574.55 mi (924.65 km) |
| Drobeta-Turnu Severin to Silea | 509.09 mi (819.31 km) |
| Drobeta-Turnu Severin to Silvi Paese | 450.37 mi (724.81 km) |
| Drobeta-Turnu Severin to Sinalunga | 551.57 mi (887.66 km) |
| Drobeta-Turnu Severin to Siniscola | 714.95 mi (1,150.59 km) |
| Drobeta-Turnu Severin to Sinnai | 781.47 mi (1,257.65 km) |
| Drobeta-Turnu Severin to Siracusa | 648.39 mi (1,043.49 km) |
| Drobeta-Turnu Severin to Solaro | 664.02 mi (1,068.63 km) |
| Drobeta-Turnu Severin to Soliera | 575.55 mi (926.25 km) |
