| Drobeta-Turnu Severin to Solofra | 474.68 mi (763.92 km) |
| Drobeta-Turnu Severin to Somma Lombardo | 682.64 mi (1,098.61 km) |
| Drobeta-Turnu Severin to Somma Vesuviana | 490.70 mi (789.71 km) |
| Drobeta-Turnu Severin to Sommacampagna | 578.24 mi (930.59 km) |
| Drobeta-Turnu Severin to Sona | 579.10 mi (931.97 km) |
| Drobeta-Turnu Severin to Sondrio | 628.30 mi (1,011.15 km) |
| Drobeta-Turnu Severin to Sora | 497.41 mi (800.51 km) |
| Drobeta-Turnu Severin to Sorbolo | 598.43 mi (963.09 km) |
| Drobeta-Turnu Severin to Soresina | 626.42 mi (1,008.13 km) |
| Drobeta-Turnu Severin to Sorisole | 636.63 mi (1,024.55 km) |
| Drobeta-Turnu Severin to Sorrento | 503.20 mi (809.82 km) |
| Drobeta-Turnu Severin to Sorso | 760.74 mi (1,224.29 km) |
| Drobeta-Turnu Severin to Sortino | 650.80 mi (1,047.36 km) |
| Drobeta-Turnu Severin to Soverato Marina | 517.51 mi (832.86 km) |
| Drobeta-Turnu Severin to Sovicille | 574.94 mi (925.28 km) |
