| Drobeta-Turnu Severin to Spello | 509.94 mi (820.67 km) |
| Drobeta-Turnu Severin to Spilamberto | 572.04 mi (920.60 km) |
| Drobeta-Turnu Severin to Spilimbergo | 484.69 mi (780.03 km) |
| Drobeta-Turnu Severin to Spinea | 514.97 mi (828.76 km) |
| Drobeta-Turnu Severin to Spoleto | 514.03 mi (827.26 km) |
| Drobeta-Turnu Severin to Spoltore | 451.73 mi (726.99 km) |
| Drobeta-Turnu Severin to Spresiano | 512.07 mi (824.10 km) |
| Drobeta-Turnu Severin to Squinzano | 372.78 mi (599.93 km) |
| Drobeta-Turnu Severin to Statte | 394.51 mi (634.90 km) |
| Drobeta-Turnu Severin to Stezzano | 636.60 mi (1,024.50 km) |
| Drobeta-Turnu Severin to Strada | 566.44 mi (911.60 km) |
| Drobeta-Turnu Severin to Stradella | 653.84 mi (1,052.25 km) |
| Drobeta-Turnu Severin to Striano | 487.36 mi (784.34 km) |
| Drobeta-Turnu Severin to Subiaco | 514.90 mi (828.66 km) |
| Drobeta-Turnu Severin to Sulmona | 473.06 mi (761.32 km) |
