| Drobeta-Turnu Severin to Sangeorz-Bai | 212.69 mi (342.30 km) |
| Drobeta-Turnu Severin to Sannicolau Mare | 139.83 mi (225.03 km) |
| Drobeta-Turnu Severin to Santana | 131.04 mi (210.88 km) |
| Drobeta-Turnu Severin to Satu Mare | 218.41 mi (351.49 km) |
| Drobeta-Turnu Severin to Scobinti | 279.84 mi (450.36 km) |
| Drobeta-Turnu Severin to Scornicesti | 93.57 mi (150.59 km) |
| Drobeta-Turnu Severin to Sebes | 101.99 mi (164.13 km) |
| Drobeta-Turnu Severin to Seini | 217.32 mi (349.75 km) |
| Drobeta-Turnu Severin to Sfantu-Gheorghe | 174.68 mi (281.12 km) |
| Drobeta-Turnu Severin to Sibiu | 108.45 mi (174.53 km) |
| Drobeta-Turnu Severin to Sighetu Marmatiei | 235.28 mi (378.64 km) |
| Drobeta-Turnu Severin to Sighisoara | 150.83 mi (242.73 km) |
| Drobeta-Turnu Severin to Simeria | 85.87 mi (138.20 km) |
| Drobeta-Turnu Severin to Sinaia | 150.16 mi (241.66 km) |
| Drobeta-Turnu Severin to Slatina | 85.59 mi (137.75 km) |
