| St. Louis (Missouri) to Seguin | 764.73 mi (1,230.72 km) |
| Denver (Colorado) to Seguin | 804.41 mi (1,294.57 km) |
| Atlanta (Georgia) to Seguin | 846.25 mi (1,361.90 km) |
| Phoenix (Arizona) to Seguin | 874.69 mi (1,407.68 km) |
| Tampa (Florida) to Seguin | 945.65 mi (1,521.88 km) |
| Chicago (Illinois) to Seguin | 1,022.40 mi (1,645.40 km) |
| Minneapolis (Minnesota) to Seguin | 1,092.73 mi (1,758.58 km) |
| Las Vegas (Nevada) to Seguin | 1,101.20 mi (1,772.21 km) |
| Miami (Florida) to Seguin | 1,116.53 mi (1,796.88 km) |
| San Diego (California) to Seguin | 1,152.16 mi (1,854.22 km) |
| Riverside (California) to Seguin | 1,178.10 mi (1,895.98 km) |
| Detroit (Michigan) to Seguin | 1,209.70 mi (1,946.82 km) |
| Los Angeles (California) to Seguin | 1,237.25 mi (1,991.16 km) |
| Washington (District of Columbia) to Seguin | 1,354.07 mi (2,179.16 km) |
| Baltimore (Maryland) to Seguin | 1,384.49 mi (2,228.12 km) |
| Philadelphia (Pennsylvania) to Seguin | 1,475.77 mi (2,375.02 km) |
| San Francisco (California) to Seguin | 1,510.68 mi (2,431.20 km) |
| Brooklyn (New York) to Seguin | 1,550.24 mi (2,494.88 km) |
| New York (New York) to Seguin | 1,552.59 mi (2,498.65 km) |
| Queens (New York) to Seguin | 1,560.21 mi (2,510.91 km) |
| Boston (Massachusetts) to Seguin | 1,730.80 mi (2,785.45 km) |
| Portland (Oregon) to Seguin | 1,731.51 mi (2,786.59 km) |
| Seattle (Washington) to Seguin | 1,797.14 mi (2,892.21 km) |
| Houston (Texas) to Seguin | 155.40 mi (250.09 km) |
| Dallas (Texas) to Seguin | 232.50 mi (374.17 km) |
