| Edmonton to Southern Pines (North Carolina) | 3,933.37 mi (6,330.14 km) |
| Edmonton to Southfield (Michigan) | 3,751.29 mi (6,037.12 km) |
| Edmonton to Southgate (Michigan) | 3,761.40 mi (6,053.39 km) |
| Edmonton to Southlake (Texas) | 4,751.24 mi (7,646.39 km) |
| Edmonton to Spanaway (Washington) | 4,811.34 mi (7,743.10 km) |
| Edmonton to Spanish Fork (Utah) | 4,885.29 mi (7,862.11 km) |
| Edmonton to Spanish Lake (Missouri) | 4,191.66 mi (6,745.83 km) |
| Edmonton to Spanish Springs (Nevada) | 5,160.21 mi (8,304.55 km) |
| Edmonton to Sparks (Nevada) | 5,166.36 mi (8,314.45 km) |
| Edmonton to Spartanburg (South Carolina) | 4,048.46 mi (6,515.37 km) |
| Edmonton to Spearfish (South Dakota) | 4,396.78 mi (7,075.93 km) |
| Edmonton to Speedway (Indiana) | 3,990.68 mi (6,422.38 km) |
| Edmonton to Spencer (Iowa) | 4,164.21 mi (6,701.65 km) |
| Edmonton to Spokane (Washington) | 4,644.12 mi (7,473.99 km) |
| Edmonton to Spokane Valley (Washington) | 4,638.84 mi (7,465.49 km) |
