| Edwardsville to Orbetello | 4,966.28 mi (7,992.46 km) |
| Edwardsville to Oria | 5,309.96 mi (8,545.56 km) |
| Edwardsville to Oristano | 4,959.27 mi (7,981.18 km) |
| Edwardsville to Orta Nova | 5,196.09 mi (8,362.30 km) |
| Edwardsville to Orte | 5,013.36 mi (8,068.22 km) |
| Edwardsville to Ortona | 5,099.40 mi (8,206.69 km) |
| Edwardsville to Orvieto | 4,991.43 mi (8,032.93 km) |
| Edwardsville to Orzinuovi | 4,795.27 mi (7,717.24 km) |
| Edwardsville to Osimo | 5,014.76 mi (8,070.48 km) |
| Edwardsville to Ospitaletto | 4,794.69 mi (7,716.31 km) |
| Edwardsville to Ostuni | 5,297.55 mi (8,525.58 km) |
| Edwardsville to Ottaviano | 5,166.85 mi (8,315.25 km) |
| Edwardsville to Ovada | 4,773.46 mi (7,682.14 km) |
| Edwardsville to Ozieri | 4,949.45 mi (7,965.38 km) |
| Edwardsville to Paceco | 5,209.06 mi (8,383.18 km) |
