| Enna to Santeramo in Colle | 260.37 mi (419.02 km) |
| Enna to Santo Stefano di Magra | 509.54 mi (820.03 km) |
| Enna to Santo Stino di Livenza | 570.42 mi (918.00 km) |
| Enna to Sarezzo | 596.89 mi (960.60 km) |
| Enna to Sarno | 225.53 mi (362.95 km) |
| Enna to Saronno | 619.00 mi (996.18 km) |
| Enna to Sarzana | 505.51 mi (813.54 km) |
| Enna to Sassari | 376.19 mi (605.41 km) |
| Enna to Sasso Marconi | 497.94 mi (801.36 km) |
| Enna to Sassuolo | 515.83 mi (830.14 km) |
| Enna to Sava | 263.89 mi (424.68 km) |
| Enna to Saviano | 232.05 mi (373.46 km) |
| Enna to Savigliano | 598.99 mi (963.98 km) |
| Enna to Savignano sul Panaro | 507.01 mi (815.96 km) |
| Enna to Savignano sul Rubicone | 461.40 mi (742.56 km) |
