| Enniskillen to Sestu | 1,299.24 mi (2,090.93 km) |
| Enniskillen to Settimo Torinese | 933.45 mi (1,502.24 km) |
| Enniskillen to Seveso | 953.30 mi (1,534.18 km) |
| Enniskillen to Sezze | 1,297.37 mi (2,087.92 km) |
| Enniskillen to Siano | 1,388.71 mi (2,234.92 km) |
| Enniskillen to Siena | 1,144.41 mi (1,841.76 km) |
| Enniskillen to Signa | 1,112.80 mi (1,790.87 km) |
| Enniskillen to Silea | 1,063.89 mi (1,712.17 km) |
| Enniskillen to Silvi Paese | 1,278.52 mi (2,057.58 km) |
| Enniskillen to Sinalunga | 1,163.12 mi (1,871.86 km) |
| Enniskillen to Siniscola | 1,242.53 mi (1,999.65 km) |
| Enniskillen to Sinnai | 1,302.16 mi (2,095.62 km) |
| Enniskillen to Siracusa | 1,612.87 mi (2,595.66 km) |
| Enniskillen to Solaro | 952.87 mi (1,533.49 km) |
| Enniskillen to Soliera | 1,058.97 mi (1,704.25 km) |
