| Esch-sur-Alzette to Sacile | 388.71 mi (625.57 km) |
| Esch-sur-Alzette to Sala Consilina | 783.71 mi (1,261.27 km) |
| Esch-sur-Alzette to Salemi | 875.17 mi (1,408.45 km) |
| Esch-sur-Alzette to Salerno | 743.52 mi (1,196.58 km) |
| Esch-sur-Alzette to Salo | 342.76 mi (551.61 km) |
| Esch-sur-Alzette to Salsomaggiore Terme | 373.98 mi (601.86 km) |
| Esch-sur-Alzette to Saluzzo | 342.64 mi (551.43 km) |
| Esch-sur-Alzette to Salzano | 395.98 mi (637.26 km) |
| Esch-sur-Alzette to Samarate | 298.20 mi (479.90 km) |
| Esch-sur-Alzette to San Benedetto del Tronto | 588.68 mi (947.39 km) |
| Esch-sur-Alzette to San Biagio di Callalta | 397.57 mi (639.83 km) |
| Esch-sur-Alzette to San Bonifacio | 376.00 mi (605.11 km) |
| Esch-sur-Alzette to San Casciano in Val di Pesa | 472.95 mi (761.13 km) |
| Esch-sur-Alzette to San Cataldo | 920.66 mi (1,481.65 km) |
| Esch-sur-Alzette to San Cesareo | 623.95 mi (1,004.14 km) |
