| Esch-sur-Alzette to Santa Venerina | 934.38 mi (1,503.73 km) |
| Esch-sur-Alzette to Santeramo in Colle | 796.73 mi (1,282.22 km) |
| Esch-sur-Alzette to Santo Stefano di Magra | 412.70 mi (664.17 km) |
| Esch-sur-Alzette to Santo Stino di Livenza | 406.03 mi (653.44 km) |
| Esch-sur-Alzette to Sarezzo | 330.54 mi (531.95 km) |
| Esch-sur-Alzette to Sarno | 731.58 mi (1,177.36 km) |
| Esch-sur-Alzette to Saronno | 303.02 mi (487.66 km) |
| Esch-sur-Alzette to Sarzana | 416.70 mi (670.62 km) |
| Esch-sur-Alzette to Sassari | 618.77 mi (995.81 km) |
| Esch-sur-Alzette to Sasso Marconi | 430.80 mi (693.30 km) |
| Esch-sur-Alzette to Sassuolo | 409.64 mi (659.25 km) |
| Esch-sur-Alzette to Sava | 844.26 mi (1,358.71 km) |
| Esch-sur-Alzette to Saviano | 722.95 mi (1,163.47 km) |
| Esch-sur-Alzette to Savigliano | 343.78 mi (553.25 km) |
| Esch-sur-Alzette to Savignano sul Panaro | 420.15 mi (676.16 km) |
