| Esch-sur-Alzette to Savignano sul Rubicone | 480.97 mi (774.04 km) |
| Esch-sur-Alzette to Savona | 377.39 mi (607.35 km) |
| Esch-sur-Alzette to Scafati | 732.76 mi (1,179.26 km) |
| Esch-sur-Alzette to Scalea | 823.28 mi (1,324.94 km) |
| Esch-sur-Alzette to Scandiano | 404.72 mi (651.33 km) |
| Esch-sur-Alzette to Scandicci | 467.19 mi (751.87 km) |
| Esch-sur-Alzette to Schio | 361.93 mi (582.47 km) |
| Esch-sur-Alzette to Sciacca | 900.63 mi (1,449.43 km) |
| Esch-sur-Alzette to Scicli | 980.26 mi (1,577.58 km) |
| Esch-sur-Alzette to Scordia | 951.58 mi (1,531.41 km) |
| Esch-sur-Alzette to Scorze | 393.80 mi (633.76 km) |
| Esch-sur-Alzette to Sedico | 367.47 mi (591.39 km) |
| Esch-sur-Alzette to Sedriano | 310.32 mi (499.42 km) |
| Esch-sur-Alzette to Segni | 637.48 mi (1,025.92 km) |
| Esch-sur-Alzette to Segrate | 317.09 mi (510.30 km) |
