| Esch-sur-Alzette to Sestu | 720.96 mi (1,160.27 km) |
| Esch-sur-Alzette to Settimo Torinese | 312.86 mi (503.51 km) |
| Esch-sur-Alzette to Seveso | 304.15 mi (489.48 km) |
| Esch-sur-Alzette to Sezze | 649.77 mi (1,045.70 km) |
| Esch-sur-Alzette to Siano | 734.57 mi (1,182.18 km) |
| Esch-sur-Alzette to Siena | 496.92 mi (799.72 km) |
| Esch-sur-Alzette to Signa | 463.24 mi (745.51 km) |
| Esch-sur-Alzette to Silea | 396.17 mi (637.57 km) |
| Esch-sur-Alzette to Silvi Paese | 617.92 mi (994.45 km) |
| Esch-sur-Alzette to Sinalunga | 513.01 mi (825.61 km) |
| Esch-sur-Alzette to Siniscola | 642.42 mi (1,033.88 km) |
| Esch-sur-Alzette to Sinnai | 721.92 mi (1,161.81 km) |
| Esch-sur-Alzette to Siracusa | 976.25 mi (1,571.13 km) |
| Esch-sur-Alzette to Solaro | 304.69 mi (490.36 km) |
| Esch-sur-Alzette to Soliera | 402.48 mi (647.72 km) |
