| Esch-sur-Alzette to Spello | 551.28 mi (887.20 km) |
| Esch-sur-Alzette to Spilamberto | 416.80 mi (670.78 km) |
| Esch-sur-Alzette to Spilimbergo | 395.74 mi (636.87 km) |
| Esch-sur-Alzette to Spinea | 399.45 mi (642.86 km) |
| Esch-sur-Alzette to Spoleto | 565.17 mi (909.55 km) |
| Esch-sur-Alzette to Spoltore | 623.92 mi (1,004.10 km) |
| Esch-sur-Alzette to Spresiano | 388.38 mi (625.03 km) |
| Esch-sur-Alzette to Squinzano | 858.34 mi (1,381.37 km) |
| Esch-sur-Alzette to Statte | 823.36 mi (1,325.06 km) |
| Esch-sur-Alzette to Stezzano | 316.01 mi (508.57 km) |
| Esch-sur-Alzette to Strada | 480.61 mi (773.47 km) |
| Esch-sur-Alzette to Stradella | 342.25 mi (550.80 km) |
| Esch-sur-Alzette to Striano | 730.19 mi (1,175.13 km) |
| Esch-sur-Alzette to Subiaco | 624.72 mi (1,005.39 km) |
| Esch-sur-Alzette to Sulmona | 640.73 mi (1,031.15 km) |
