| Esch-sur-Alzette to Sangeorz-Bai | 867.39 mi (1,395.94 km) |
| Esch-sur-Alzette to Sannicolau Mare | 718.17 mi (1,155.78 km) |
| Esch-sur-Alzette to Santana | 749.17 mi (1,205.68 km) |
| Esch-sur-Alzette to Satu Mare | 779.22 mi (1,254.03 km) |
| Esch-sur-Alzette to Scobinti | 968.21 mi (1,558.18 km) |
| Esch-sur-Alzette to Scornicesti | 935.35 mi (1,505.31 km) |
| Esch-sur-Alzette to Sebes | 850.95 mi (1,369.47 km) |
| Esch-sur-Alzette to Seini | 797.70 mi (1,283.78 km) |
| Esch-sur-Alzette to Sfantu-Gheorghe | 951.85 mi (1,531.85 km) |
| Esch-sur-Alzette to Sibiu | 881.23 mi (1,418.20 km) |
| Esch-sur-Alzette to Sighetu Marmatiei | 821.77 mi (1,322.52 km) |
| Esch-sur-Alzette to Sighisoara | 898.40 mi (1,445.84 km) |
| Esch-sur-Alzette to Simeria | 829.27 mi (1,334.59 km) |
| Esch-sur-Alzette to Sinaia | 955.51 mi (1,537.74 km) |
| Esch-sur-Alzette to Slatina | 931.88 mi (1,499.71 km) |
