| Esch-sur-Alzette to Santander | 624.05 mi (1,004.32 km) |
| Esch-sur-Alzette to Santany | 714.64 mi (1,150.11 km) |
| Esch-sur-Alzette to Santiago de Compostela | 829.60 mi (1,335.12 km) |
| Esch-sur-Alzette to Santiago del Teide | 1,894.58 mi (3,049.03 km) |
| Esch-sur-Alzette to Santiponce | 1,025.90 mi (1,651.02 km) |
| Esch-sur-Alzette to Santomera | 863.49 mi (1,389.66 km) |
| Esch-sur-Alzette to Santona | 612.96 mi (986.47 km) |
| Esch-sur-Alzette to Santurce-Antiguo | 604.04 mi (972.11 km) |
| Esch-sur-Alzette to Sarria | 789.67 mi (1,270.85 km) |
| Esch-sur-Alzette to Sauzal | 1,871.36 mi (3,011.66 km) |
| Esch-sur-Alzette to Sedavi | 762.61 mi (1,227.30 km) |
| Esch-sur-Alzette to Segorbe | 737.67 mi (1,187.17 km) |
| Esch-sur-Alzette to Segovia | 767.01 mi (1,234.38 km) |
| Esch-sur-Alzette to Senmanat | 575.70 mi (926.50 km) |
| Esch-sur-Alzette to Sesena | 802.57 mi (1,291.61 km) |
