| Festus to Enterprise (Nevada) | 1,371.77 mi (2,207.65 km) |
| Festus to Enumclaw (Washington) | 1,704.90 mi (2,743.77 km) |
| Festus to Ephrata (Pennsylvania) | 772.92 mi (1,243.90 km) |
| Festus to Erie (Colorado) | 793.22 mi (1,276.57 km) |
| Festus to Erie (Pennsylvania) | 607.99 mi (978.46 km) |
| Festus to Erlanger (Kentucky) | 319.04 mi (513.45 km) |
| Festus to Escanaba (Michigan) | 547.25 mi (880.72 km) |
| Festus to Escondido (California) | 1,531.38 mi (2,464.53 km) |
| Festus to Española (New Mexico) | 875.15 mi (1,408.41 km) |
| Festus to Essex (Maryland) | 755.33 mi (1,215.58 km) |
| Festus to Essex Junction (Vermont) | 993.48 mi (1,598.86 km) |
| Festus to Estelle (Louisiana) | 578.90 mi (931.65 km) |
| Festus to Estero (Florida) | 956.39 mi (1,539.15 km) |
| Festus to Euclid (Ohio) | 525.29 mi (845.37 km) |
| Festus to Eufaula (Alabama) | 527.49 mi (848.92 km) |
