| Festus to Seymour (Tennessee) | 400.31 mi (644.23 km) |
| Festus to Shady Hills (Florida) | 815.34 mi (1,312.16 km) |
| Festus to Shafter (California) | 1,596.61 mi (2,569.50 km) |
| Festus to Shaker Heights (Ohio) | 520.69 mi (837.97 km) |
| Festus to Shakopee (Minnesota) | 479.83 mi (772.21 km) |
| Festus to Sharon (Pennsylvania) | 565.88 mi (910.70 km) |
| Festus to Sharonville (Ohio) | 331.61 mi (533.68 km) |
| Festus to Shasta Lake (California) | 1,704.59 mi (2,743.27 km) |
| Festus to Shawnee (Kansas) | 243.68 mi (392.17 km) |
| Festus to Shawnee (Oklahoma) | 413.11 mi (664.84 km) |
| Festus to Sheboygan (Wisconsin) | 406.17 mi (653.67 km) |
| Festus to Shelby (North Carolina) | 530.52 mi (853.79 km) |
| Festus to Shelbyville (Indiana) | 265.10 mi (426.63 km) |
| Festus to Shelbyville (Kentucky) | 281.20 mi (452.55 km) |
| Festus to Shelbyville (Tennessee) | 288.42 mi (464.16 km) |
