| Festus to Southern Pines (North Carolina) | 644.02 mi (1,036.45 km) |
| Festus to Southfield (Michigan) | 477.45 mi (768.38 km) |
| Festus to Southgate (Michigan) | 469.09 mi (754.92 km) |
| Festus to Southlake (Texas) | 524.85 mi (844.66 km) |
| Festus to Spanaway (Washington) | 1,723.82 mi (2,774.22 km) |
| Festus to Spanish Fork (Utah) | 1,142.07 mi (1,837.98 km) |
| Festus to Spanish Lake (Missouri) | 40.80 mi (65.67 km) |
| Festus to Spanish Springs (Nevada) | 1,568.67 mi (2,524.52 km) |
| Festus to Sparks (Nevada) | 1,571.73 mi (2,529.45 km) |
| Festus to Spartanburg (South Carolina) | 522.02 mi (840.11 km) |
| Festus to Spearfish (South Dakota) | 817.68 mi (1,315.92 km) |
| Festus to Speedway (Indiana) | 248.47 mi (399.88 km) |
| Festus to Spencer (Iowa) | 421.36 mi (678.11 km) |
| Festus to Spokane (Washington) | 1,504.25 mi (2,420.86 km) |
| Festus to Spokane Valley (Washington) | 1,495.29 mi (2,406.44 km) |
