| Festus to Superior (Colorado) | 798.97 mi (1,285.83 km) |
| Festus to Superior (Wisconsin) | 591.68 mi (952.22 km) |
| Festus to Surprise (Arizona) | 1,268.73 mi (2,041.83 km) |
| Festus to Susanville (California) | 1,613.70 mi (2,596.99 km) |
| Festus to Sussex (Wisconsin) | 358.39 mi (576.77 km) |
| Festus to Suwanee (Georgia) | 456.04 mi (733.93 km) |
| Festus to Swansea (Illinois) | 32.42 mi (52.17 km) |
| Festus to Sweetwater (Florida) | 1,039.87 mi (1,673.51 km) |
| Festus to Sweetwater (Texas) | 688.84 mi (1,108.59 km) |
| Festus to Sycamore (Illinois) | 276.41 mi (444.84 km) |
| Festus to Sylacauga (Alabama) | 418.85 mi (674.08 km) |
| Festus to Sylvania (Ohio) | 428.83 mi (690.13 km) |
| Festus to Syosset (New York) | 917.34 mi (1,476.31 km) |
| Festus to Syracuse (New York) | 817.49 mi (1,315.62 km) |
| Festus to Syracuse (Utah) | 1,166.01 mi (1,876.51 km) |
